Coronavirus Disease 2019 (COVID-19) (2022)

COVID-19 Science Briefs provide a summary of the scientific evidence used to inform specific CDC guidance and recommendations. The Science Briefs reflect the scientific evidence, and CDC’s understanding of it, on a specific topic at the time of the Brief’s publication. Though CDC seeks to update Science Briefs when and as appropriate, given ongoing changes in scientific evidence an individual Science Brief might not reflect CDC’s current understanding of that topic. As scientific evidence and available information on COVID-19 change, Science Briefs will be systematically archived as historic reference materials.

Page First Published Nov 10, 2020 | View Page Updates

  • Background
  • Source Control to Block Exhaled Virus
  • Filtration for Wearer Protection
  • Human Studies of Masking and SARS-CoV-2 Transmission
  • Potential Adverse Health Effects of Mask Wearing
  • Conclusions
(Video) Coronavirus disease (COVID-19)


SARS-CoV-2 infection is transmitted predominantly by inhalation of respiratory droplets generated when people cough, sneeze, sing, talk, or breathe. CDC recommends community use ofmasks to prevent transmission of SARS-CoV-2. Masks are primarily intended to reduce the emission of virus-laden droplets by the wearer (“source control”), which is especially relevant for asymptomatic or presymptomatic infected wearers who feel well and may be unaware of their infectiousness to others (estimated to account for more than 50% of SARS-CoV-2 transmissions).1, 2Masks also help reduce inhalation of these droplets by the wearer (“filtration for wearer protection”). The community benefit of masking for SARS-CoV-2 control is due to the combination of these two effects (source control and filtration for wearer protection); individual prevention benefit increases with increasing numbers of people using masks consistently and correctly.

Source Control to Block Exhaled Virus

Multi-layer cloth masks block release of exhaled respiratory particles into the environment,3-6along with any microorganisms associated with these particles.7, 8Cloth masks not only effectively block most large droplets (i.e., 20-30 microns and larger),9but they can also block the exhalation of fine droplets and particles (also often referred to as aerosols) smaller than 10 microns3, 5 which increase in number with the volume of speech10-12and specific types of phonation.13Multi-layer cloth masks can both block 50-70% of these fine droplets and particles3, 14and limit the forward spread of those that are not captured.5, 6, 15, 16Upwards of 80% blockage has been achieved in human experiments,4with cloth masks in some studies performing on par with surgical masks as barriers for sourcecontrol.3, 9, 14, 17In one study, conducted prior to widespread circulation of the Delta variant, masks worked equally well for blocking aerosolized particles containing both “wild-type” virus and the Alpha variant (a more infectious variant).17

Filtration for Wearer Protection

Studies demonstrate that cloth mask materials can also reduce wearers’ exposure to infectious droplets through filtration, including filtration of fine droplets and particles less than 10 microns. The relative filtration effectiveness of various masks has varied widely across studies, in large part due to variation in experimental design and particle sizes analyzed. Multiple layers of cloth with higher thread counts have demonstrated superior performance compared to single layers of cloth with lower thread counts, in some cases filtering nearly 50% of fine particles less than 1 micron.14, 18-30Some materials (e.g., polypropylene) may enhance filtering effectiveness by generating triboelectric charge (a form of static electricity) that enhances capture of charged particles20 while others (e.g., silk) may help repel moist droplets31and reduce fabric wetting and thus maintain breathability and comfort. In addition to the number of layers and choice of materials, other techniques can improve wearer protection by improving fit and thereby filtration capacity. Examples include but are not limited to mask fitters, knotting-and-tucking the ear loops of medical procedures masks, using a cloth mask placed over a medical procedure mask, and nylon hosiery sleeves.32-36

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Human Studies of Masking and SARS-CoV-2 Transmission

  • A large, well-designed cluster-randomized trial in Bangladesh in late 2020 found that surgical or cloth mask distribution, role-modeling, and active mask promotion tripled mask use to 42.3% in intervention villages compared to 13.3% in comparison villages. In villages receiving mask interventions, symptomatic seroprevalence of SARS-CoV-2 was reduced by approximately 9% relative to comparison villages. In villages randomized to receive surgical masks, symptomatic seroprevalence of SARS-CoV-2 was significantly lower (relative reduction 11.1% overall). The results of this study show that even modest increases in community use of masks can effectively reduce symptomatic SARS-CoV-2 infections (COVID-19).37
  • A study of an outbreak aboard the USS Theodore Roosevelt, an environment notable for congregate living quarters and close working environments, found that use of face coverings on-board was associated with a 70% reduced risk of infection.38
  • In a study of 124 Beijing households with > 1 laboratory-confirmed case of SARS-CoV-2 infection, mask use by the index patient and family contacts before the index patient developed symptoms reduced secondary transmission within the households by 79%.39
  • A study examining SARS-CoV-2 secondary attack rates among eight public K-12 school districts in Massachusetts (70 schools with >33,000 enrolled students) during the 2020–21 school year found an unadjusted secondary attack rate of 11.7% for unmasked versus 1.7% for masked interactions.40
  • A retrospective case-control study from Thailand documented that, among more than 1,000 persons interviewed as part of contact tracing investigations, those who reported having always worn a mask during high-risk exposures experienced a greater than 70% reduced risk of acquiring infection compared with persons who did not wear masks under these circumstances.41
  • During July 15–August 31, 2021, when Delta was the predominant strain circulating in the U.S., about one in five K–12 public non-charter schools open for in-person learning in Maricopa and Pima Counties, Arizona, experienced a school-associated outbreak. Outbreaks were three and a half times more likely (adjusted odds ratio 3.5, 95% confidence interval 1.8-6.6) in schools without mask mandates.42
  • In a nationwide analysis of data collected during July 1-September 4, 2021, U.S. counties without school mask requirements experienced larger increases in pediatric COVID-19 case rates (18.53 per 100,000 per day more cases) after the start of school compared with counties with school mask requirements.43
  • An investigation of a high-exposure event in the U.S., in which 2 symptomatically ill hair stylists interacted for an average of 15 minutes with each of 139 clients during an 8-day period, found that none of the 67 clients who subsequently consented to an interview and testing developed infection. The stylists and all clients universally wore masks in the salon as required by local ordinance and company policy at the time.44
  • Investigations involving infected passengers aboard flights longer than 10 hours strongly suggest that masking prevented in-flight transmissions, as demonstrated by the absence of infection developing in other passengers and crew in the 14 days following exposure.45, 46

At least ten studies have confirmed the benefit of universal masking in community level analyses: in a unified hospital system,47a German city,48two U.S. states,49, 50a panel of 15 U.S. states and Washington, D.C.,51, 52as well as both Canada53and the U.S.54-56nationally. Each analysis demonstrated that, following directives from organizational and political leadership for universal masking, new infections fell significantly. Two of these studies51, 52and an additional analysis of data from 200 countries that included the U.S.56also demonstrated reductions in mortality. Another 10-site study showed reductions in hospitalization growth rates following mask mandate implementation.54 A separate series of cross-sectional surveys in the U.S. suggested that a 10% increase in self-reported mask wearing tripled the likelihood of stopping community transmission.57An economic analysis using U.S. data found that, given these effects, increasing universal masking by 15% could prevent the need for lockdowns and reduce associated losses of up to $1 trillion or about 5% of gross domestic product.52

Two studies have been improperly characterized by some sources as showing that surgical or cloth masks offer no benefit.58,59 A community-based randomized control trial in Denmark during 2020 assessed whether the use of surgical masks reduced the SARS-CoV-2 infection rate among wearers (personal protection) by more than 50%.58 Findings were inconclusive,58most likely because the actual reduction in infections was lower. The study was too small (i.e., enrolled about 0.1% of the population) to assess whether masks could decrease transmission from wearers to others (source control). A second study of 14 hospitals in Vietnam during 2015 found that cloth masks were inferior to surgical masks for protection against clinical upper respiratory illness or laboratory-confirmed viral infection.59The study had a number of limitations including the lack of a true control (no mask) group for comparison, limited source control as hospitalized patients and staff were not masked, unblinded study arm assignments potentially biasing self-reporting of illness, and the washing and re-use of cloth masks by users introducing the risk of infection from self-washing. A follow up study in 2020 found that healthcare workers whose cloth masks were laundered by the hospital were protected equally as well as those that wore medical masks.60

Potential Adverse Health Effects of Mask Wearing


Research supports that under most circumstances, mask wearing has no significant adverse health effects for wearers.Studies of healthy hospital workers, older adults, and adults with chronic obstructive pulmonary disease (COPD) reported no to minimal changes in oxygen or carbon dioxide levels while wearing a cloth or surgical mask either during rest or moderate physical activity.61-65 The safety of mask use during low to moderate levels of exercise has been confirmed in studies of healthy adults and adolescents.64, 66-70 Some,71-74 but not all,67 studies have found that during intense exercise, especially when approaching the aerobic threshold, wearing a mask can increase dyspnea (difficulty breathing), perceived exertion, and claustrophobia, and produce modest negative effects on measured cardiopulmonary parameters. In some people, face masks worn for longer durations might be associated with skin reactions such as acne, itching, dry skin and worsening of existing dermatoses.75-77 Wearing a surgical mask and N95 respirator may have a higher risk of skin reactions compared with a cloth mask.76-78

(Video) COVID-19 is still knocking at our door. Stay up to date with vaccines and mask up to stay safe.


A study of 60 elementary school children reported no adverse cardiovascular (e.g., heart rate) or pulmonary (e.g., peripheral oxygen saturation) effects among children while wearing a cloth face covering in a classroom for 30 consecutive minutes of instructional time.79 A separate study observed no oxygen desaturation or respiratory distress after 60 minutes of monitoring among children less than 2 years of age when masked during normal play.80 A randomized trial among 40 children aged 3–10 years old scheduled for elective surgery, found that protective surgical face masks could be used safely in the postoperative period.81 In a prospective school-based cohort study of children aged 10–17 years who wore masks for 6–7 hours during the school day, some children self-reported general (4–7%) or situation-specific (2–4%) side-effects such as skin irritation, headache, or difficulty breathing during physical education.82

The potential impact of masks on language and emotional development has been examined in several studies.83-89 Some research suggests children and adults, and especially toddlers (aged 3–5 years) can have difficulty inferring emotion from facial features presented on photographs of persons with their lower facial features covered by a mask.83 However, a study of 7- to 13-year-old children determined the decrement in emotional inference observed when the lower half of a photographed face was covered with a mask was equivalent to that associated with covering the eyes with sunglasses, leading the authors to conclude that in combination with other contextual cues, masks are unlikely to produce serious impairments of children’s social interactions.84 A study of 2-year-old children concluded that they were able to recognize familiar words presented without a mask and when hearing words through opaque masks.85 Among children with autism spectrum disorders (ASD), interventions including positive reinforcement and coaching caregivers to teach mask wearing have improved participants’ ability to wear a face mask.86-88 These findings suggest that even children who may have difficulty wearing a mask can do so effectively through targeted interventions.


Experimental and epidemiologic data support community masking to reduce the spread of SARS-CoV-2, including alpha and delta variants, among adults and children. The prevention benefit of masking is derived from the combination of source control and wearer protection. The relationship between source control and wearer protection is likely complementary and possibly synergistic, so that individual benefit increases with increasing community mask use. Mask use has been found to be safe and is not associated with clinically significant impacts on respiration or gas exchange under most circumstances, except for intense exercise. The limited available data indicate no clear evidence that masking impairs emotional or language development in children. Further research is needed to assess masks, particularly to identify the combinations of materials that maximize both their blocking and filtering effectiveness, as well as fit, comfort, durability, and consumer appeal.

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Table: Summary of studies that have assessed the effect of mask wearing on COVID-19 infection risks
Type of investigationLocationStudy monthsPopulation studiedInterventionOutcome
Abaluck37Cluster-randomized trialBangladeshNov 2020–April 2021342,183 adults in 572 villagesMask promotion strategiesIn villages receiving mask interventions, symptomatic seroprevalence of SARS-CoV-2 was reduced by approximately 9% (adjusted prevalence ratio 0.91, 95% CI 0.82-1.00) relative to comparison villages
Payne38Cohort studyUSS Theodore Roosevelt, Guam (USA)March 2020382 U.S. Navy service membersMask wearing (self-report)Masking reduced risk of infection by 70% (unadjusted OR 0.30, 95% CI = 0.17–0.52)
Wang Y39Cohort studyHouseholds in Beijing (China)February–March 2020124 households of diagnosed cases comprising 335 peopleMask wearing by index cases or >1 household member prior to index case’s diagnosis (self-report)Masking reduced risk of secondary infection by 79% (adjusted OR 0.21, 95% CI = 0.06–0.79)
Hendrix44Cohort studyHair salon in Springfield, MO (USA)May 20202 symptomatically infected stylists and 139 patronsUniversal masking in salon (by local ordinance and company policy)No COVID-19 infections among 67 patrons who were tested in follow-up
Doung-Ngern41Case-control studyBangkok (Thailand)April–May 2020839 close contacts of 211 index casesMask wearing by contact at time of high-risk exposure to case (self-report)Always having used a mask reduced infection by 77% (adjusted OR 0.23, 95% CI = 0.096–0.60)
Gallaway49Population-based interventionArizona (USA)January–August 2020State populationMandatory mask wearing in publicTemporal association between institution of masking policy and subsequent decline in new diagnoses
Rader57Serial cross-sectional surveysUSAJune–July 2020374,021 persons who completed web-based surveysSelf-reported mask wearing in grocery stores and in the homes of family or friends10% increase in mask wearing tripled the likelihood of stopping community transmission (adjusted OR 3.53, 95% CI = 2.03-6.43)
Wang X47Population-based intervention with trend analysisBoston, MA (USA)March– April 20209,850 healthcare workers (HCW)Universal masking of HCW and patients, Mass General Brigham health care systemEstimated daily decline in new diagnoses among HCW of 0.49%
Mitze48Population-based intervention with trend analysisJena (Thuringia), GermanyApril 2020City population aged >15 yearsMandatory mask wearing in public spaces (e.g., public transport, shops)Estimated daily decline in new diagnoses of 1.28 percentage points
Van Dyke50Population-based intervention with trend analysisKansas (USA)June– August 2020State populationMandatory mask wearing in public spacesEstimated case rate per 100,000 decreased by 0.08 in counties with mask mandates but increased by 0.11 in those without
Lyu and Wehby51Population-based intervention with trend analysis15 U.S. states and Washington, DCMarch– May 2020State populationMandatory mask wearing in publicEstimated overall initial daily decline in new diagnoses of 0.9%, grew to 2.0% at 21 days following mandates
Joo54Population-based intervention with trend analysisUSAMarch–October 2020State populationsMandatory mask wearing in publicEstimated decline in weekly hospitalization rates by 5.6 percentage points for adults aged 18–64 years after mandate implementation, compared with growth rates during the 4 weeks preceding implementation of the mandate
Guy56Population-based intervention with trend analysis2,313 counties, USAMarch–December 2020County populationMandatory mask wearing in publicEstimated overall initial daily decline in new diagnoses of 0.5%, grew to 1.8% at 81–100 days following mandates; estimated overall initial daily decline in deaths of 0.7%, grew to 1.9% at 81-100 days following mask mandate implementation
Jehn42Population-based intervention with trend analysisArizona (USA)July–August 20211,020 K–12 schoolsSchool mask policiesOdds of a school-associated COVID-19 outbreak in schools without a mask requirement were 3.5 times higher than those in schools with an early mask requirement (OR = 3.5; 95% CI = 1.8–6.9)
Budzyn43Population-based intervention with trend analysisUSAJuly–September 2021520 countiesSchool mask requirementsIncreases in pediatric COVID-19 case rates during the start of the 2021–22 school year were smaller in U.S. counties with school mask requirements than in those without school mask requirements
Karaivanov53Counterfactual modeling using national dataCanadaMarch–August 2020County populationMandatory mask wearing indoorsEstimated weekly 22% decline in new diagnoses following mask mandates
Chernozhukov55Counterfactual modeling using national dataUSAMarch–May 2020State populationMandatory mask wearing for employees in public businessesNationally mandating face masks for employees early in the pandemic could have reduced weekly growth rate of cases and deaths by more than 10 percentage points in late April and 34% (95% CI: 19–47%) fewer deaths nationally by end of May
Leffler90Population-based intervention with trend analysis169 countriesJanuary–May 2020County populationMask wearing by tradition, mandate, or recommendationDuration of mask wearing by the public was negatively associated with per-capita mortality from COVID-19

Summary of Updates

As of December 6, 2021

  • Data were added from studies published since the last update. These studies address the association of mask wearing with new infections, including infections related to SARS-CoV-2 variants of concern. All of these studies demonstrated a benefit.
  • A section was added on mask wearing among children.
(Video) COVID-19 (Coronavirus Disease 19) August Update- causes, symptoms, diagnosis, treatment, pathology


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