Dramamine, (dimenhydrinate) dosing, indications, interactions, adverse effects, and more (2022)

  • albuterol

    dimenhydrinate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • alfentanil

    dimenhydrinate and alfentanil both increase sedation. Use Caution/Monitor.

  • alprazolam

    dimenhydrinate and alprazolam both increase sedation. Use Caution/Monitor.

  • amitriptyline

    dimenhydrinate and amitriptyline both increase sedation. Use Caution/Monitor.

  • amobarbital

    dimenhydrinate and amobarbital both increase sedation. Use Caution/Monitor.

  • amoxapine

    dimenhydrinate and amoxapine both increase sedation. Use Caution/Monitor.

  • apomorphine

    dimenhydrinate and apomorphine both increase sedation. Use Caution/Monitor.

  • arformoterol

    dimenhydrinate increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • aripiprazole

    dimenhydrinate and aripiprazole both increase sedation. Use Caution/Monitor.

  • armodafinil

    dimenhydrinate increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • azelastine

    azelastine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • baclofen

    dimenhydrinate and baclofen both increase sedation. Use Caution/Monitor.

  • belladonna and opium

    dimenhydrinate and belladonna and opium both increase sedation. Use Caution/Monitor.

  • benperidol

    dimenhydrinate and benperidol both increase sedation. Use Caution/Monitor.

  • benzphetamine

    dimenhydrinate increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • benztropine

    dimenhydrinate increases toxicity of benztropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects.

  • brexanolone

    brexanolone, dimenhydrinate.Either increases toxicity of the other by sedation. Use Caution/Monitor.

  • brompheniramine

    brompheniramine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • buprenorphine

    dimenhydrinate and buprenorphine both increase sedation. Use Caution/Monitor.

  • buprenorphine buccal

    dimenhydrinate and buprenorphine buccal both increase sedation. Use Caution/Monitor.

  • butabarbital

    dimenhydrinate and butabarbital both increase sedation. Use Caution/Monitor.

  • butalbital

    dimenhydrinate and butalbital both increase sedation. Use Caution/Monitor.

  • butorphanol

    dimenhydrinate and butorphanol both increase sedation. Use Caution/Monitor.

  • caffeine

    dimenhydrinate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • carbinoxamine

    carbinoxamine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • carisoprodol

    dimenhydrinate and carisoprodol both increase sedation. Use Caution/Monitor.

  • chloral hydrate

    dimenhydrinate and chloral hydrate both increase sedation. Use Caution/Monitor.

  • chlordiazepoxide

    dimenhydrinate and chlordiazepoxide both increase sedation. Use Caution/Monitor.

  • chlorpheniramine

    chlorpheniramine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • chlorpromazine

    dimenhydrinate and chlorpromazine both increase sedation. Use Caution/Monitor.

  • chlorzoxazone

    dimenhydrinate and chlorzoxazone both increase sedation. Use Caution/Monitor.

  • cinnarizine

    cinnarizine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • clemastine

    clemastine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • clobazam

    dimenhydrinate, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

  • clomipramine

    dimenhydrinate and clomipramine both increase sedation. Use Caution/Monitor.

  • clonazepam

    dimenhydrinate and clonazepam both increase sedation. Use Caution/Monitor.

  • clorazepate

    dimenhydrinate and clorazepate both increase sedation. Use Caution/Monitor.

  • clozapine

    dimenhydrinate and clozapine both increase sedation. Use Caution/Monitor.

  • codeine

    dimenhydrinate and codeine both increase sedation. Use Caution/Monitor.

  • cyclizine

    cyclizine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • cyclobenzaprine

    dimenhydrinate and cyclobenzaprine both increase sedation. Use Caution/Monitor.

  • cyproheptadine

    cyproheptadine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • dantrolene

    dimenhydrinate and dantrolene both increase sedation. Use Caution/Monitor.

  • daridorexant

    dimenhydrinate and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

  • desflurane

    desflurane and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • desipramine

    dimenhydrinate and desipramine both increase sedation. Use Caution/Monitor.

  • deutetrabenazine

    dimenhydrinate and deutetrabenazine both increase sedation. Use Caution/Monitor.

  • dexchlorpheniramine

    dexchlorpheniramine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • dexfenfluramine

    dimenhydrinate increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dexmedetomidine

    dimenhydrinate and dexmedetomidine both increase sedation. Use Caution/Monitor.

  • dexmethylphenidate

    dimenhydrinate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dextroamphetamine

    dimenhydrinate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dextromoramide

    dimenhydrinate and dextromoramide both increase sedation. Use Caution/Monitor.

  • diamorphine

    dimenhydrinate and diamorphine both increase sedation. Use Caution/Monitor.

  • diazepam

    dimenhydrinate and diazepam both increase sedation. Use Caution/Monitor.

  • diazepam intranasal

    diazepam intranasal, dimenhydrinate.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.

  • diethylpropion

    dimenhydrinate increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • difelikefalin

    difelikefalin and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • difenoxin hcl

    dimenhydrinate and difenoxin hcl both increase sedation. Use Caution/Monitor.

  • diphenhydramine

    dimenhydrinate and diphenhydramine both increase sedation. Use Caution/Monitor.

  • diphenoxylate hcl

    dimenhydrinate and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

  • dipipanone

    dimenhydrinate and dipipanone both increase sedation. Use Caution/Monitor.

  • dobutamine

    dimenhydrinate increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • donepezil transdermal

    donepezil transdermal, dimenhydrinate.Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.

  • dopamine

    dimenhydrinate increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dopexamine

    dimenhydrinate increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dosulepin

    dimenhydrinate and dosulepin both increase sedation. Use Caution/Monitor.

  • doxepin

    dimenhydrinate and doxepin both increase sedation. Use Caution/Monitor.

  • doxylamine

    dimenhydrinate and doxylamine both increase sedation. Use Caution/Monitor.

  • droperidol

    dimenhydrinate and droperidol both increase sedation. Use Caution/Monitor.

  • ephedrine

    dimenhydrinate increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • epinephrine

    dimenhydrinate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • epinephrine racemic

    dimenhydrinate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • esketamine intranasal

    esketamine intranasal, dimenhydrinate.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

  • estazolam

    dimenhydrinate and estazolam both increase sedation. Use Caution/Monitor.

  • ethanol

    dimenhydrinate and ethanol both increase sedation. Use Caution/Monitor.

  • etomidate

    etomidate and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • fenfluramine

    dimenhydrinate increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • fentanyl

    fentanyl, dimenhydrinate.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

  • fentanyl intranasal

    fentanyl intranasal, dimenhydrinate.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

  • fentanyl transdermal

    fentanyl transdermal, dimenhydrinate.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

  • fentanyl transmucosal

    fentanyl transmucosal, dimenhydrinate.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may increase risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.

  • flibanserin

    dimenhydrinate and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.

  • fluphenazine

    dimenhydrinate and fluphenazine both increase sedation. Use Caution/Monitor.

  • flurazepam

    dimenhydrinate and flurazepam both increase sedation. Use Caution/Monitor.

  • formoterol

    dimenhydrinate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • gabapentin

    gabapentin, dimenhydrinate.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

  • gabapentin enacarbil

    gabapentin enacarbil, dimenhydrinate.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

  • ganaxolone

    dimenhydrinate and ganaxolone both increase sedation. Use Caution/Monitor.

  • glycopyrronium tosylate topical

    glycopyrronium tosylate topical, dimenhydrinate.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.

  • gotu kola

    gotu kola increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

  • haloperidol

    dimenhydrinate and haloperidol both increase sedation. Use Caution/Monitor.

  • hawthorn

    hawthorn increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

  • hops

    hops increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

  • hyaluronidase

    dimenhydrinate decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.

  • hydromorphone

    dimenhydrinate and hydromorphone both increase sedation. Use Caution/Monitor.

  • hydroxyzine

    dimenhydrinate and hydroxyzine both increase sedation. Use Caution/Monitor.

  • iloperidone

    dimenhydrinate and iloperidone both increase sedation. Use Caution/Monitor.

  • imipramine

    dimenhydrinate and imipramine both increase sedation. Use Caution/Monitor.

  • incobotulinumtoxinA

    dimenhydrinate, incobotulinumtoxinA.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects.

  • isoproterenol

    dimenhydrinate increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • kava

    kava increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

  • ketamine

    ketamine and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • ketotifen, ophthalmic

    dimenhydrinate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

  • lasmiditan

    lasmiditan, dimenhydrinate.Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

  • lemborexant

    lemborexant, dimenhydrinate.Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.

  • levalbuterol

    dimenhydrinate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • levorphanol

    dimenhydrinate and levorphanol both increase sedation. Use Caution/Monitor.

  • lisdexamfetamine

    dimenhydrinate increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • lofepramine

    dimenhydrinate and lofepramine both increase sedation. Use Caution/Monitor.

  • lofexidine

    dimenhydrinate and lofexidine both increase sedation. Use Caution/Monitor.

  • loprazolam

    dimenhydrinate and loprazolam both increase sedation. Use Caution/Monitor.

  • lorazepam

    dimenhydrinate and lorazepam both increase sedation. Use Caution/Monitor.

  • lormetazepam

    dimenhydrinate and lormetazepam both increase sedation. Use Caution/Monitor.

  • loxapine

    dimenhydrinate and loxapine both increase sedation. Use Caution/Monitor.

  • loxapine inhaled

    dimenhydrinate and loxapine inhaled both increase sedation. Use Caution/Monitor.

  • lurasidone

    lurasidone, dimenhydrinate.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

  • maprotiline

    dimenhydrinate and maprotiline both increase sedation. Use Caution/Monitor.

  • marijuana

    dimenhydrinate and marijuana both increase sedation. Use Caution/Monitor.

  • melatonin

    dimenhydrinate and melatonin both increase sedation. Use Caution/Monitor.

  • meperidine

    dimenhydrinate and meperidine both increase sedation. Use Caution/Monitor.

  • meprobamate

    dimenhydrinate and meprobamate both increase sedation. Use Caution/Monitor.

  • metaproterenol

    dimenhydrinate increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • metaxalone

    dimenhydrinate and metaxalone both increase sedation. Use Caution/Monitor.

  • methadone

    dimenhydrinate and methadone both increase sedation. Use Caution/Monitor.

  • methamphetamine

    dimenhydrinate increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • methocarbamol

    dimenhydrinate and methocarbamol both increase sedation. Use Caution/Monitor.

  • methylenedioxymethamphetamine

    dimenhydrinate increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • midazolam

    dimenhydrinate and midazolam both increase sedation. Use Caution/Monitor.

  • midazolam intranasal

    midazolam intranasal, dimenhydrinate.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

  • midodrine

    dimenhydrinate increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • mirtazapine

    dimenhydrinate and mirtazapine both increase sedation. Use Caution/Monitor.

  • modafinil

    dimenhydrinate increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • morphine

    dimenhydrinate and morphine both increase sedation. Use Caution/Monitor.

  • motherwort

    dimenhydrinate and motherwort both increase sedation. Use Caution/Monitor.

  • moxonidine

    dimenhydrinate and moxonidine both increase sedation. Use Caution/Monitor.

  • nabilone

    dimenhydrinate and nabilone both increase sedation. Use Caution/Monitor.

  • nalbuphine

    dimenhydrinate and nalbuphine both increase sedation. Use Caution/Monitor.

  • norepinephrine

    dimenhydrinate increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • nortriptyline

    dimenhydrinate and nortriptyline both increase sedation. Use Caution/Monitor.

  • olanzapine

    dimenhydrinate and olanzapine both increase sedation. Use Caution/Monitor.

  • opium tincture

    dimenhydrinate and opium tincture both increase sedation. Use Caution/Monitor.

  • orphenadrine

    dimenhydrinate and orphenadrine both increase sedation. Use Caution/Monitor.

  • oxazepam

    dimenhydrinate and oxazepam both increase sedation. Use Caution/Monitor.

  • oxycodone

    dimenhydrinate and oxycodone both increase sedation. Use Caution/Monitor.

  • oxymorphone

    dimenhydrinate and oxymorphone both increase sedation. Use Caution/Monitor.

  • paliperidone

    dimenhydrinate and paliperidone both increase sedation. Use Caution/Monitor.

  • papaveretum

    dimenhydrinate and papaveretum both increase sedation. Use Caution/Monitor.

  • papaverine

    dimenhydrinate and papaverine both increase sedation. Use Caution/Monitor.

  • passion flower

    passion flower increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

  • pentazocine

    dimenhydrinate and pentazocine both increase sedation. Use Caution/Monitor.

  • pentobarbital

    dimenhydrinate and pentobarbital both increase sedation. Use Caution/Monitor.

  • perphenazine

    dimenhydrinate and perphenazine both increase sedation. Use Caution/Monitor.

  • phendimetrazine

    dimenhydrinate increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • phenobarbital

    dimenhydrinate and phenobarbital both increase sedation. Use Caution/Monitor.

  • phentermine

    dimenhydrinate increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • phenylephrine

    dimenhydrinate increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • phenylephrine PO

    dimenhydrinate increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

  • pholcodine

    dimenhydrinate and pholcodine both increase sedation. Use Caution/Monitor.

  • pimozide

    dimenhydrinate and pimozide both increase sedation. Use Caution/Monitor.

  • pirbuterol

    dimenhydrinate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • pregabalin

    pregabalin, dimenhydrinate.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

  • primidone

    dimenhydrinate and primidone both increase sedation. Use Caution/Monitor.

  • prochlorperazine

    dimenhydrinate and prochlorperazine both increase sedation. Use Caution/Monitor.

  • promethazine

    dimenhydrinate and promethazine both increase sedation. Use Caution/Monitor.

  • propofol

    propofol and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • propylhexedrine

    dimenhydrinate increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • protriptyline

    dimenhydrinate and protriptyline both increase sedation. Use Caution/Monitor.

  • quazepam

    dimenhydrinate and quazepam both increase sedation. Use Caution/Monitor.

  • quetiapine

    dimenhydrinate and quetiapine both increase sedation. Use Caution/Monitor.

  • ramelteon

    dimenhydrinate and ramelteon both increase sedation. Use Caution/Monitor.

  • rimabotulinumtoxinB

    dimenhydrinate, rimabotulinumtoxinB.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Anticholinergics may enhance botulinum toxin effects. Closely monitor for increased neuromuscular blockade.

  • risperidone

    dimenhydrinate and risperidone both increase sedation. Use Caution/Monitor.

  • salmeterol

    dimenhydrinate increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • scullcap

    dimenhydrinate and scullcap both increase sedation. Use Caution/Monitor.

  • secobarbital

    dimenhydrinate and secobarbital both increase sedation. Use Caution/Monitor.

  • sevoflurane

    sevoflurane and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • shepherd's purse

    dimenhydrinate and shepherd's purse both increase sedation. Use Caution/Monitor.

  • stiripentol

    stiripentol, dimenhydrinate.Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

  • sufentanil

    dimenhydrinate and sufentanil both increase sedation. Use Caution/Monitor.

  • tapentadol

    dimenhydrinate and tapentadol both increase sedation. Use Caution/Monitor.

  • temazepam

    dimenhydrinate and temazepam both increase sedation. Use Caution/Monitor.

  • terbutaline

    dimenhydrinate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • thioridazine

    dimenhydrinate and thioridazine both increase sedation. Use Caution/Monitor.

  • thiothixene

    dimenhydrinate and thiothixene both increase sedation. Use Caution/Monitor.

  • topiramate

    dimenhydrinate and topiramate both increase sedation. Modify Therapy/Monitor Closely.

  • tramadol

    dimenhydrinate and tramadol both increase sedation. Use Caution/Monitor.

  • trazodone

    dimenhydrinate and trazodone both increase sedation. Use Caution/Monitor.

  • triazolam

    dimenhydrinate and triazolam both increase sedation. Use Caution/Monitor.

  • triclofos

    dimenhydrinate and triclofos both increase sedation. Use Caution/Monitor.

  • trifluoperazine

    dimenhydrinate and trifluoperazine both increase sedation. Use Caution/Monitor.

  • trihexyphenidyl

    dimenhydrinate increases toxicity of trihexyphenidyl by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects.

  • trimipramine

    dimenhydrinate and trimipramine both increase sedation. Use Caution/Monitor.

  • triprolidine

    dimenhydrinate and triprolidine both increase sedation. Use Caution/Monitor.

  • valerian

    valerian increases effects of dimenhydrinate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

  • xylometazoline

    dimenhydrinate increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • yohimbine

    dimenhydrinate increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ziconotide

    dimenhydrinate and ziconotide both increase sedation. Use Caution/Monitor.

  • ziprasidone

    dimenhydrinate and ziprasidone both increase sedation. Use Caution/Monitor.

  • zotepine

    dimenhydrinate and zotepine both increase sedation. Use Caution/Monitor.

  • aclidinium

    dimenhydrinate increases toxicity of aclidinium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • anticholinergic/sedative combos

    dimenhydrinate increases toxicity of anticholinergic/sedative combos by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • ashwagandha

    ashwagandha increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

  • atracurium

    dimenhydrinate increases toxicity of atracurium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • atropine

    dimenhydrinate increases toxicity of atropine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • atropine IV/IM

    dimenhydrinate increases toxicity of atropine IV/IM by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • belladonna alkaloids

    dimenhydrinate increases toxicity of belladonna alkaloids by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • belladonna and opium

    dimenhydrinate increases toxicity of belladonna and opium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • brimonidine

    brimonidine increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

  • cisatracurium

    dimenhydrinate increases toxicity of cisatracurium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • cyclizine

    dimenhydrinate increases toxicity of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • cyclobenzaprine

    dimenhydrinate increases toxicity of cyclobenzaprine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • darifenacin

    dimenhydrinate increases toxicity of darifenacin by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • dicyclomine

    dimenhydrinate increases toxicity of dicyclomine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • diphenhydramine

    dimenhydrinate increases toxicity of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • eucalyptus

    dimenhydrinate and eucalyptus both increase sedation. Minor/Significance Unknown.

  • fesoterodine

    dimenhydrinate increases toxicity of fesoterodine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • flavoxate

    dimenhydrinate increases toxicity of flavoxate by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • glycopyrrolate

    dimenhydrinate increases toxicity of glycopyrrolate by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • glycopyrrolate inhaled

    dimenhydrinate increases toxicity of glycopyrrolate inhaled by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • henbane

    dimenhydrinate increases toxicity of henbane by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • homatropine

    dimenhydrinate increases toxicity of homatropine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • hyoscyamine

    dimenhydrinate increases toxicity of hyoscyamine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • hyoscyamine spray

    dimenhydrinate increases toxicity of hyoscyamine spray by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • ipratropium

    dimenhydrinate increases toxicity of ipratropium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • meclizine

    dimenhydrinate increases toxicity of meclizine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • methscopolamine

    dimenhydrinate increases toxicity of methscopolamine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • nettle

    nettle increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

  • onabotulinumtoxinA

    dimenhydrinate increases toxicity of onabotulinumtoxinA by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • oxybutynin

    dimenhydrinate increases toxicity of oxybutynin by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • oxybutynin topical

    dimenhydrinate increases toxicity of oxybutynin topical by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • oxybutynin transdermal

    dimenhydrinate increases toxicity of oxybutynin transdermal by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • pancuronium

    dimenhydrinate increases toxicity of pancuronium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • pralidoxime

    dimenhydrinate increases toxicity of pralidoxime by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • propantheline

    dimenhydrinate increases toxicity of propantheline by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • rapacuronium

    dimenhydrinate increases toxicity of rapacuronium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • rocuronium

    dimenhydrinate increases toxicity of rocuronium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • sage

    dimenhydrinate and sage both increase sedation. Minor/Significance Unknown.

  • scopolamine

    dimenhydrinate increases toxicity of scopolamine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • Siberian ginseng

    Siberian ginseng increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

  • solifenacin

    dimenhydrinate increases toxicity of solifenacin by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • tiotropium

    dimenhydrinate increases toxicity of tiotropium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • tolterodine

    dimenhydrinate increases toxicity of tolterodine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • trospium chloride

    dimenhydrinate increases toxicity of trospium chloride by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

  • vecuronium

    dimenhydrinate increases toxicity of vecuronium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

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