How Long Do Muscle Relaxers Stay In Your System? (2022)

A muscle relaxant is a drug that affects skeletal muscle function and decreases muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term “muscle relaxant” is not a class of drugs but used to refer to two major therapeutic groups: neuromuscular blockers and spasmolytics.

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Muscle relaxers are used in addition to rest, physical therapy, and other measures to relieve discomfort. They are typically prescribed for short-term use to treat acute, painful musculoskeletal conditions. Muscle relaxers are occasionally prescribed for chronic pain (pain lasting longer than 3 months).

How do muscle relaxants work?

Muscle relaxants work by causing the muscles to become less tense or stiff, which in turn reduces pain and discomfort. They do this in different ways. Baclofen, diazepam, methocarbamol, and tizanidine act on the central nervous system (brain and spinal cord). Dantrolene works directly on the muscle. Cannabis extract works on the brain and spinal cord as well as the muscles. Because dantrolene only works on the muscles, it is thought to have fewer side effects compared with other muscle relaxants. For this reason, dantrolene is often the first muscle relaxant to be prescribed for people with long-term muscle spasms.

How Long Do Muscle Relaxers Stay In Your System?

The specific drug taken, drug-taking habits, amount consumed, age, weight, and gender all influence the length of time a drug stays in your system. Other factors include how the drug was taken, whether other drugs were used, ethnicity and medical conditions such as kidney problems can determine how long muscle relaxers stay in the body.

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Since muscle relaxers are not a class of drugs they do not all have the same chemical structure, work the same way or stay in your body at the same rate. In this article we have listed the common muscle relaxants and how long they last in your body:

Baclofen. Sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity such as from a spinal cord injury or multiple sclerosis. It may also be used for hiccups and muscle spasms near the end of life. It is taken by mouth or by delivery into the spinal canal. Baclofen is rapidly absorbed, although absorption may be reduced with higher dosages.

There is a wide variation in the way individuals respond to baclofen, with some people reporting a reduction in symptoms of muscle spasm within a few hours, whereas for some others it may take several weeks. The drug is predominantly excreted unchanged by the kidneys. The half-life of baclofen is roughly 2–4 hours; it, therefore, needs to be administered frequently throughout the day to control spasticity appropriately.

Benzodiazepines. In addition to treating anxiety, alcohol withdrawal, and seizure disorders, such as epilepsy, benzodiazepines can also treat muscle spasms and skeletal pain. Benzodiazepines, such as diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril), are typically only intended for short-term use. Benzodiazepines are well known for their strong muscle-relaxing properties and can be useful in the treatment of muscle spasms, although tolerance often develops to their muscle relaxant effects. Benzodiazepines can stay in urine for 3 to 6 weeks, hair up to 90 days, and blood for 2-3 days. ALSO READ: How Long Does Blue B707 Pill Last?

Carisoprodol (Soma). Carisoprodol relaxes muscles and eases pain and stiffness caused by acute bone and muscle problems, often caused by an injury. It is taken by mouth in tablet form and is also available in combination with aspirin or aspirin and codeine. Carisoprodol can be habit-forming, particularly if used in conjunction with alcohol or other drugs that have a sedative effect, including opioids (such as codeine). Carisoprodol is absorbed and begins to have effects after 30 minutes and the effects last for 4 to 6 hours. Both carisoprodol and its metabolite meprobamate are excreted in the urine and can be detected for several days after the last dose.

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Chlorzoxazone (Lorzone). Chlorzoxazone is used for the relief of discomfort from acute, painful, musculoskeletal conditions. Chlorzoxazone is available as a tablet. Common side effects include drowsiness, dizziness, and nausea. Chlorzoxazone is not recommended for people with liver disease. Chlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide. Less than one percent of a dose of Chlorzoxazone is excreted unchanged in the urine in 24 hours.

Cyclobenzaprine (Amrix, Fexmid, FlexePax Kit, FusePaq Tabradol). Cyclobenzaprine popularly known by the brand Flexeril eases stiffness and pain from muscle cramps, also called muscle spasms. It is available as a tablet and extended-release capsule. Cyclobenzaprine itself is not intended for long-term use (more than 2 to 3 weeks). Levels of Cyclobenzaprine in your system peak approximately three to four hours after taking the medication, after which time the effects begin to diminish. Most people feel the effects of Cyclobenzaprine for about four to six hours.

However, just because you stop feeling the effects of Cyclobenzaprine does not mean that the medication has left your system. Cyclobenzaprine is detected in a urine sample for anywhere from three to eight days after taking your last dose, and it appears in a blood test and drug test for up to 3.75 days after it is last ingested. Cyclobenzaprine stays in your saliva for 36 hours after use, and it is unknown how long it stays in your system. ALSO READ: How To Flush Flexeril Out Of Your System

Dantrolene (Dantrium). Dantrolene helps control chronic spasticity related to spinal injuries. It is also used for conditions such as stroke, multiple sclerosis, and cerebral palsy. Dantrolene is taken as a capsule or intravenous powder for injection. Drowsiness and sensitivity to light are common side effects. It can cause severe liver problems, and should not be taken by people with active liver disease. The duration and intensity of skeletal muscle relaxation are related to the dosage and blood levels. The mean biologic half-life of Dantrolene sodium in adults is 8.7 hours after a 100-mg dose.

Metaxalone (Skelaxin, Metaxall, and Metaxall CP, Lorvatus PharmaPak). Metaxalone targets pain and muscle spasms from sprains, strains, and muscle injuries. It is available as a tablet or injection. Peak plasma concentrations of metaxalone occur approximately 3 hours after a 400 mg oral dose under fasted conditions. Thereafter, metaxalone concentrations decline log-linearly with a terminal half-life of 9.0 ± 4.8 hours.

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Methocarbamol (Robaxin, Robaxin-750). Methocarbamol eases acute muscle and bone pain. It can be taken as a tablet or by injection. Methocarbamol is generally not recommended to people with renal disease or failure or a history of allergic reaction to the medication. At the time of ingestion, Methocarbamol can last in the urine of an individual for a total of four hours. This can vary from person to person depending on their health or age. ALSO READ: Does Methocarbamol Show Up As On A Drug Test

Orphenadrine. Orphenadrine is a medication used to relieve pain and stiffness caused by muscle injuries. It is available as an extended-release tablet. Common side effects include dry mouth, lightheadedness, difficult urination, heartburn, nausea, and vomiting. It is generally not recommended to people with previous sensitivities to the ingredients, myasthenia gravis, those with glaucoma, or certain types of ulcers. Orphenadrine is readily absorbed from the gastrointestinal tract and is almost completely metabolized to at least eight metabolites. Orphenadrine and its metabolites are excreted from the body in the urine, with a half-life of 14 hours.

Tizanidine (Comfort Pac with Tizanidine, Zanaflex). Tizanidine is used to treat muscle spasms caused by spinal cord injuries and other conditions such as multiple sclerosis. Tizanidine is available in tablet and capsule form and absorbs differently depending on whether it is taken on an empty stomach or with food. Tizanidine has a short “half-life” of only about 150 minutes, which means that the body clears the drug within a few hours. Common side effects include dry mouth, dizziness, constipation, and tiredness. It should not be used by people taking fluvoxamine or ciprofloxacin or those who have liver disease.

How Long Do Muscle Relaxers Stay In Your System? (2)

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FAQs

How Long Do Muscle Relaxers Stay In Your System? ›

As an estimate then , after taking a dose of Flexeril

Flexeril
What is cyclobenzaprine? Cyclobenzaprine is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.
https://www.drugs.com › cyclobenzaprine
it should be out of your system within 5.5 days to 16.5 days. Flexeril has a long half life of between 1 and 3 days. This is the time it takes for your body to reduce the plasma drug levels by half.

How long do muscle relaxers stay in your body? ›

In general, muscle relaxers act as central nervous system depressants and cause a sedative effect or prevent your nerves from sending pain signals to your brain. The onset of action is rapid and effects typically last from 4-6 hours.

How long does a 5 mg muscle relaxer stay in your system? ›

The drug may be detectable in urine anywhere from 5 to 13 days after someone takes Flexeril. In blood, Flexeril may be detectable from 2 to 4 hours after someone uses it, and for up to 10 days. Flexeril may show up in a hair-based drug test for up to three days after someone uses it.

Can cyclobenzaprine cause a positive drug test? ›

Several other substances also cause false-positive tricyclic antidepressant toxic screen results, including certain antipsychotic medications, antihistamines, and the muscle relaxant cyclobenzaprine.

Do muscle relaxers make you tired the next day? ›

Sleepiness. Because muscle relaxers are total body relaxants, they typically induce grogginess or sleepiness. As a result, it is not safe to drive or make important decisions while taking muscle relaxers. Muscle relaxers are often suggested for evening use due to their sedative effect.

How long does a 10 mg muscle relaxer last? ›

The effects of immediate-release tablets last for four to six hours. The effects of extended-release tablets last for 24 hours. 5mg of cyclobenzaprine is reportedly as effective as 10mg of cyclobenzaprine, with fewer side effects.

Do muscle relaxers affect the heart? ›

Effects on the heart warning: This drug may cause heart arrhythmias (heart rate or rhythm problems). Your risk may be higher if you take a drug to treat depression or if you already have heart problems. If these issues aren't treated, they can lead to a heart attack or stroke.

How long does it take for cyclobenzaprine to wear off? ›

When taking Flexeril, brain effects occur within an hour of consumption. Effects wear off after about 12-24 hours.

What does cyclobenzaprine do to your body? ›

Cyclobenzaprine is used to help relax certain muscles in your body. It helps relieve pain, stiffness, and discomfort caused by strains, sprains, or injuries to your muscles.

What do muscle relaxers do? ›

Muscle relaxants work by causing the muscles to become less tense or stiff, which in turn reduces pain and discomfort. They do this in different ways. Baclofen, diazepam, methocarbamol and tizanidine act on the central nervous system (brain and spinal cord).

Is a muscle relaxer a narcotic? ›

Methocarbamol isn't a narcotic. It's a central nervous system (CNS) depressant and muscle relaxant used to treat muscle spasms, tension, and pain. It may be mistaken for a narcotic due to side effects like drowsiness and dizziness, which can feel like a drug “high.”

Is cyclobenzaprine controlled substance? ›

Cyclobenzaprine is not currently controlled under the Controlled Substances Act.

Is a cyclobenzaprine a benzo? ›

Answer. No, cyclobenzaprine is a 'prine' not a 'pine' (benzodiazepine)... Benzodiazepines effect the neurotransmitter GABA (the 'feel good' neurotransmitter).

What is the safest muscle relaxer? ›

Taken as 800 mg tablets 3 to 4 times a day, metaxalone (Skelaxin) has the fewest reported side effects and lowest sedation potential of the muscle relaxants based on clinical studies. Simply put, it is the best-tolerated of the muscle relaxants.

Do muscle relaxers help with inflammation? ›

These are ideal because they reduce inflammation, which is the ultimate cause of the pain. If that fails, and the spasms are not resolving on their own with rest, icing, hydration, and proper nutrition, the second line of defense is for your pain management specialist to prescribe muscle relaxers.

Do muscle relaxers help with pain? ›

Muscle relaxers are used in addition to rest, physical therapy, and other measures to relieve discomfort. They are typically prescribed for short-term use to treat acute, painful musculoskeletal conditions. Muscle relaxers are occasionally prescribed for chronic pain (pain lasting longer than 3 months).

What are the side effects of muscle relaxers? ›

Side Effects
  • Tiredness, drowsiness, or sedation effect.
  • Fatigue or weakness.
  • Dizziness.
  • Dry mouth.
  • Depression.
  • Decreased blood pressure.
Oct 17, 2020

How many muscle relaxers can u take in a day? ›

For oral dosage form (tablets): Adults and children 15 years of age and older—10 milligrams (mg) 3 times a day. The largest amount should be no more than 60 mg (six 10-mg tablets) a day.

Do muscle relaxers raise or lower blood pressure? ›

Muscle relaxants used to treat muscle spasms and cramping normally don't increase blood pressure. In fact, they often lower it. As a result, muscle relaxers may not be safe to take with certain blood pressure medications.

Can muscle relaxers help with nerve pain? ›

These drugs exert their muscle-relaxing effects by inhibiting nerve signals in the brain and spinal cord and may help break the pain-spasm-pain cycle, where pain causes your muscles to spasm as a protective response, and those spasms, in turn, cause more pain.

Do muscle relaxers help with anxiety? ›

Benzodiazepines are a group of medications that can help reduce anxiety and make it easier to sleep. They are also used as a muscle relaxant, to induce sedation for surgery and other medical procedures, and in the treatment of seizures and alcohol withdrawal.

What can you not take with cyclobenzaprine? ›

Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.

What pain reliever can I take with cyclobenzaprine? ›

Cyclobenzaprine works by blocking nerve impulses that you recognize as pain and is often combined with over-the-counter (OTC) pain medications like:
  • acetaminophen (Tylenol)
  • anti-inflammatory NSAIDs like ibuprofen (Advil, Motrin) or naproxen (Aleve).
Feb 23, 2022

Is Flexeril a pain killer or muscle relaxer? ›

Flexeril is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Flexeril is used together with rest and physical therapy to treat skeletal muscle conditions such as pain, injury, or spasms. Flexeril may also be used for purposes not listed in this medication guide.

Is 10 mg of cyclobenzaprine strong? ›

The recommended dose of immediate-release cyclobenzaprine is 5 to 10mg, three times a day, while that for extended-release versions is 15 to 30 mg, once a day. Maximum daily dose for either form is 30 mg over the course of 24 hours. Taking more than recommended may result in adverse effects or overdose.

Does cyclobenzaprine make you feel weird? ›

A cyclobenzaprine high causes feelings of sedation and mild euphoria. Those effects—and its dangers—are heightened when cyclobenzaprine is combined with other drugs, particularly central nervous system depressants such as alcohol, benzos, and barbiturates.

Is cyclobenzaprine an opioid? ›

Cyclobenzaprine is not a narcotic or an opioid. Unlike a handful of other muscle relaxers such as carisoprodol (Soma), it's not currently controlled under the Controlled Substances Act (9).

What is the strongest muscle relaxer for pain? ›

Methocarbamol. Methocarbamol works as a muscle relaxer by blocking pain sensations that reach the brain.

Do muscle relaxers actually relax muscles? ›

You might think that “muscle relaxers” do, in fact, relax your muscles. The truth is, they don't have anything to do with muscle tissue. They work on the central nervous system and cause general sedation.

How long after taking muscle relaxers can I drink? ›

Muscle relaxers stay in your system longer than 24 hours. If you must have an alcoholic beverage, it is best to wait 24 hours or longer after taking your last dose of the muscle relaxer to avoid any potentially harmful effects.

How long does it take for cyclobenzaprine to wear off? ›

When taking Flexeril, brain effects occur within an hour of consumption. Effects wear off after about 12-24 hours.

How long does Flexeril muscle relaxer stay in your system? ›

by Drugs.com

As an estimate then , after taking a dose of Flexeril it should be out of your system within 5.5 days to 16.5 days. Flexeril has a long half life of between 1 and 3 days. This is the time it takes for your body to reduce the plasma drug levels by half. Flexeril is eliminated slowly from the body.

How long does the effect of cyclobenzaprine last? ›

Cyclobenzaprine's Effectiveness Timeframe

Cyclobenzaprine works for 4-6 hours. However, the half-life of immediate-release cyclobenzaprine is 18 hours on average, with a range of 8-37 hours. The extended-release form typically has a half-life of 32-33 hours.

How long does cyclobenzaprine 10 mg last? ›

Because cyclobenzaprine's duration of action is 4 to 6 hours, reducing the dosing frequency to 10 mg BID would create a potentially painful untreated interval between doses. The alternative is administration of a lower dose (eg, 5 or 2.5 mg) TID.

What does cyclobenzaprine do to your body? ›

Cyclobenzaprine is used to help relax certain muscles in your body. It helps relieve pain, stiffness, and discomfort caused by strains, sprains, or injuries to your muscles.

What can you not take with cyclobenzaprine? ›

Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.

Does cyclobenzaprine help with anxiety? ›

Can cyclobenzaprine help with anxiety? Cyclobenzaprine should not be used for anxiety. It can cause some of the same side effects that many anti-anxiety medications do, such as drowsiness and sleepiness. But, it is not meant to be used for this purpose.

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