Vyvanse® (lisdexamfetamine dimesylate) (2022)

MEDICATION GUIDE

VYVANSE® (Vi'- vans)

(lisdexamfetamine dimesylate)

Capsules and Chewable Tablets, CII

(Video) Vyvanse® (lisdexamfetamine dimesylate) for ADHD Mechanism Of Delivery

What is the most important information I should know about VYVANSE?

VYVANSE may cause serious side effects, including:

  • Abuse and dependence.VYVANSE, other amphetamine containing medicines, and methylphenidate have a high chance for abuse and may cause physical and psychological dependence. Your healthcare provider should check you or your child for signs of abuse and dependence before and during treatment with VYVANSE.
    • Tell your healthcare provider if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.
    • Your healthcare provider can tell you more about the differences between physical and psychological dependence and drug addiction.
  • Heart-related problems including:
    • sudden death, stroke, and heart attack in adults
    • sudden death in children who have heart problems or heart defects
    • increased blood pressure and heart rate

Your healthcare provider should check you or your child carefully for heart problems before starting treatment with VYVANSE. Tell your healthcare provider if you or your child have any heart problems, heart defects, high blood pressure, or a family history of these problems.

Your healthcare provider should check your or your child’s blood pressure and heart rate regularly during treatment with VYVANSE.

Call your healthcare provider or go to the nearest hospital emergency room right away if you or your child have any signs of heart problems such as chest pain, shortness of breath, or fainting during treatment with VYVANSE.

  • Mental (psychiatric) problems, including:
    • new or worse behavior and thought problems
    • new or worse bipolar illness
    • new psychotic symptoms (such as hearing voices, or seeing or believing things that are not real) or new manic symptoms

Tell your healthcare provider about any mental problems you or your child have or about a family history of suicide, bipolar illness, or depression.

Call your healthcare provider right away if you or your child have any new or worsening mental symptoms or problems during treatment with VYVANSE, especially hearing voices, seeing or believing things that are not real, or new manic symptoms.

What Is VYVANSE?

VYVANSE is a central nervous system (CNS) stimulant prescription medicine used for the treatment of:

  • Attention Deficit Hyperactivity Disorder (ADHD) in adults and children 6 years of age and older. VYVANSE may help increase attention and decrease impulsiveness and hyperactivity in people with ADHD.
  • Moderate to severe binge eating disorder (BED) in adults. VYVANSE may help reduce the number of binge eating days in people with BED.

VYVANSE is not for use in children under 6 years of age with ADHD.

VYVANSE is not for weight loss. It is not known if VYVANSE is safe and effective for the treatment of obesity.

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It is not known if VYVANSE is safe and effective for use in children with BED.

VYVANSE is a federally controlled substance (CII) because it contains lisdexamfetamine dimesylate that can be a target for people who abuse prescription medicines or street drugs.Keep VYVANSE in a safe place to protect it from theft. Never give your VYVANSE to anyone else because it may cause death or harm them. Selling or giving away VYVANSE may harm others and is against the law.

Do not take VYVANSE if you or your child are:

  • allergic to amphetamine products or any of the ingredients in VYVANSE. See the end of this Medication Guide for a complete list of ingredients in VYVANSE.
  • taking, or have stopped taking in the last 14 days, a medicine called a Monoamine Oxidase Inhibitor (MAOI).
  • being treated with the antibiotic linezolid or intravenous methylene blue.

Before taking VYVANSE, tell your healthcare provider about all medical conditions, including if you or your child:

  • have heart problems, heart defects, or high blood pressure
  • have mental problems including psychosis, mania, bipolar illness, or depression or have a family history of suicide, bipolar illness, or depression
  • have circulation problems in fingers and toes
  • are pregnant or plan to become pregnant. VYVANSE may harm the unborn baby.
  • are breastfeeding or plan to breastfeed. VYVANSE passes into breast milk. You should not breastfeed during treatment with VYVANSE. Talk to your healthcare provider about the best way to feed the baby during treatment with VYVANSE.

Tell your healthcare provider about all the medicines that you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

VYVANSE can affect the way other medicines work and other medicines may affect how VYVANSE works. Taking VYVANSE with other medicines can cause serious side effects. Sometimes the doses of other medicines will need to be changed while taking VYVANSE.

Especially tell your healthcare provider if you or your child take:

selective serotonin reuptake inhibitors (SSRIs)serotonin norepinephrine reuptake inhibitors (SNRIs)
medicines used to treat migraine headaches calledtriptanstricyclic antidepressants
lithiumfentanyl
tramadoltryptophan
buspironeSt. John’s Wort

Keep a list of all medicines to show your healthcare provider and pharmacist when you get a new medicine. Your healthcare provider will decide if VYVANSE can be taken with other medicines.

Do not start any new medicine during treatment with VYVANSE without talking to your healthcare provider first.

How should VYVANSE be taken?

  • Take VYVANSE exactly as prescribed by your healthcare provider.
  • Your healthcare provider may change the dose if needed.
  • Take VYVANSE 1 time each day in the morning with or without food.
  • Your healthcare provider may sometimes stop VYVANSE treatment for a while to check ADHD or BED symptoms.
  • VYVANSE comes in capsules or chewable tablets.

Taking VYVANSE Capsules:

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  • VYVANSE capsules may be swallowed whole.
  • If VYVANSE capsules cannot be swallowed whole, the capsule may be opened and the entire contents sprinkled onto yogurt, or poured into water or orange juice.
    • Using a spoon, break apart any powder that is stuck together. Stir the VYVANSE powder and yogurt, water, or orange juice until they are completely mixed together.
    • Swallow all the yogurt, water, or orange juice mixture right away.Do notstore the yogurt, water, or orange juice mixture.
    • It is normal to see a filmy coating on the inside of your glass or container after you eat or drink all the VYVANSE mixture.

Taking VYVANSE Chewable Tablets:

  • Chew VYVANSE tablets completely before swallowing.

If you or your child take too much VYVANSE, call your healthcare provider or poison control center at 1-800-222-1222 or go to the nearest hospital emergency room right away.

What should I avoid while taking VYVANSE?

Do not drive, operate machinery, or do other dangerous activities until you know how VYVANSE affects you.

What are possible side effects of VYVANSE?

VYVANSE may cause serious side effects, including:

  • See"What is the most important information I should know about VYVANSE?"
  • Slowing of growth (height and weight) in children.Children should have their height and weight checked often during treatment with VYVANSE. VYVANSE treatment may be stopped if your child is not growing or gaining weight.
  • Circulation problems in fingers and toes (Peripheral vasculopathy, including Raynaud’s phenomenon).Signs and symptoms may include:
    • Fingers or toes may feel numb, cool, painful
    • Fingers or toes may change color from pale, to blue, to red

Tell your healthcare provider if you or your child have numbness, pain, skin color change, or sensitivity to temperature in your fingers or toes.

Call your healthcare provider right away if you or your child have any signs of unexplained wounds appearing on fingers or toes during treatment with VYVANSE.

  • Serotonin Syndrome.A potentially life-threatening problem called serotonin syndrome may happen when VYVANSE is taken with certain other medicines. Stop taking VYVANSE and call your healthcare provider or go to the nearest hospital emergency room right away if you or your child develop any of the following signs and symptoms of serotonin syndrome:
agitationfast heartbeat
flushingseizures
comasweating
loss of coordinationconfusion
dizzinesstremors, stiff muscles, or muscle twitching
seeing or hearing things that are not real (hallucination)changes in blood pressure
high body temperature (hyperthermia)nausea, vomiting, diarrhea

The most common side effects of VYVANSE in children 6 to 17 years old and adults with ADHD include:

loss of appetite (anorexia)anxiety
decreased appetiteweight loss
diarrheadizziness
dry mouthirritability
trouble sleepingnausea
stomach painvomiting

The most common side effects of VYVANSE in adults with BED include:

dry mouthtrouble sleeping
decreased appetiteincreased heart rate
constipationfeeling jittery
anxiety

These are not all the possible side effects of VYVANSE.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store VYVANSE?

  • Store VYVANSE in a safe place (like a locked cabinet) and in a tightly closed container at room temperature between 68°F to 77°F (20°C to 25°C).
  • Protect VYVANSE from light.
  • Dispose of remaining, unused, or expired VYVANSE by a medicine take-back program at authorized collection sites such as retail pharmacies, hospital or clinic pharmacies, and law enforcement locations. If no take-back program or authorized collector is available, mix VYVANSE with an undesirable, nontoxic substance such as dirt, cat litter, or used coffee grounds to make it less appealing to children and pets. Place the mixture in a container such as a sealed plastic bag and throw away (discard) VYVANSE in the household trash.

Keep VYVANSE and all medicines out of the reach of children.

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General information about the safe and effective use of VYVANSE.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use VYVANSE for a condition for which it was not prescribed. Do not give VYVANSE to other people, even if they have the same symptoms that you have. It may harm them and it is against the law. You can ask your pharmacist or healthcare provider for information about VYVANSE that is written for health professionals.

What are the ingredients in VYVANSE?

Active Ingredient:lisdexamfetamine dimesylate

Capsule Inactive Ingredients:microcrystalline cellulose, croscarmellose sodium, and magnesium stearate. The capsule shells (imprinted with S489) contain gelatin, titanium dioxide, and one or more of the following: FD&C Red #3, FD&C Yellow #6, FD&C Blue #1, Black Iron Oxide, and Yellow Iron Oxide.

Chewable Tablet Inactive Ingredients:colloidal silicon dioxide, croscarmellose sodium, guar gum, magnesium stearate, mannitol, microcrystalline cellulose, sucralose, artificial strawberry flavor.

Distributed by: Takeda Pharmaceuticals America, Inc., Lexington, MA 02421.

VYVANSE® and the VYVANSE Logo® are registered trademarks of Takeda Pharmaceuticals U.S.A., Inc.

©2022 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved.

For more information, go to www.vyvanse.com or call 1-877-TAKEDA-7 (1-877-825-3327).

This Medication Guide has been approved by the U.S. Food and Drug Administration.

(Video) 2-Minute Neuroscience: Amphetamine

Revised: 10/2021
SPI-0338 Reformatted for US-LIS-1122

FAQs

What does lisdexamfetamine dimesylate do? ›

Lisdexamfetamine dimesylate is used to treat attention deficit hyperactivity disorder (ADHD) in adults and children 6 years of age and older. This medicine is also used to treat moderate to severe binge eating disorder (BED). It belongs to the group of medicines called central nervous system (CNS) stimulants.

How does Vyvanse make you feel? ›

Amphetamines such as Vyvanse can cause a feeling of euphoria or intense happiness if you take them in large doses. They can also help you feel more focused and alert. Some people misuse these drugs to get more of these effects. However, overuse or misuse can lead to dependence and withdrawal symptoms.

Is lisdexamfetamine dimesylate the same as Vyvanse? ›

Vyvanse contains the drug lisdexamfetamine dimesylate, while Ritalin contains the drug methylphenidate. Both Vyvanse and Ritalin are used to treat ADHD symptoms such as poor focus, reduced impulse control, and hyperactivity. However, they're also prescribed to treat other conditions.

What are the most common side effects of Vyvanse? ›

Nausea, vomiting, constipation, stomach/abdominal pain, loss of appetite, dry mouth, headache, nervousness, dizziness, trouble sleeping, sweating, weight loss, irritability, and restlessness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Does Vyvanse help with anxiety? ›

Often, trouble with attention causes anxiety. So if medication works to reduce symptoms, it may reduce anxiety. But Vyvanse is not an anxiety medication. And stimulant medications can sometimes increase anxiety in a small percentage of kids who take them.

How long does it take for Vyvanse to kick in? ›

How long does it usually take for Vyvanse to work? Vyvanse was shown to start working within 1.5 hours after taking the medication in a clinical trial of children ages 6 to 12 with ADHD. In a study of adults diagnosed with ADHD, the drug was shown to start working within 2 hours.

What should you not take with Vyvanse? ›

Common medications that may interact with Vyvanse include: antacids, such as those that contain aluminum. anticoagulants (blood thinners), such as warfarin, or other drugs that have blood-thinning effects such as aspirin or NSAIDs. anticonvulsants, such as phenytoin, phenobarbital, or primidone.

Does Vyvanse give you energy? ›

Vyvanse is a medication that doctors prescribe to treat attention deficit hyperactivity disorder or binge eating disorder. It is a stimulant, which helps a person to concentrate. Because Vyvanse is a stimulant, a person may feel depressed or fatigued when it begins to wear off.

What happens when you take Vyvanse and don't have ADD? ›

Many high school and college students begin to abuse Vyvanse and other stimulants for this reason. However, research has shown that when students who do not have ADHD take Vyvanse and other stimulants, they actually have a lower GPA 5.

Does Vyvanse make you lose weight? ›

What is Vyvanse? Vyvanse is a prescription medicine used for the treatment of moderate to severe binge eating disorder (B.E.D.) in adults. Vyvanse is not for weight loss.

What is the safest ADHD medication for adults? ›

In terms of non-stimulant medications, ADHD specialists recommend using atomoxetine as a first-choice medication for children and adults, followed by guanfacine or clonidine for children, and bupropion or nortriptyline for adults.

Is Vyvanse more like Adderall or Ritalin? ›

Both drugs are CNS stimulants and both are believed to have a similar mechanism of action; however, some trials indicate that Vyvanse may be more effective at relieving ADHD symptoms than Ritalin. Side effects, such as decreased appetite, weight loss, insomnia, and nausea are more common with Vyvanse than Ritalin.

Does Vyvanse help depression? ›

According to the British firm Shire, patients with partial or full remission of depression symptoms who were on primary antidepressant therapy -- and had residual cognitive impairment -- showed significant improvements in executive function when lisdexamfetamine dimesylate (Vyvanse) was added to their daily treatment.

Can Vyvanse cause permanent damage? ›

Rarely, Vyvanse can cause side effects that last longer or that cause long-term problems. These effects can include: cardiovascular (heart and blood vessel) problems, including increased blood pressure, heart attack, and stroke* blood circulation problems in your fingers and toes, including Raynaud's disease*

Does Vyvanse affect emotions? ›

The effects of a morning dose of Vyvanse typically wear off by the afternoon or evening. When they do, some patients experience a “Vyvanse crash” characterized by fatigue, tiredness, depression, irritability, anxiety, nervousness, and mood swings. Symptoms of a Vyvanse crash are very similar to Vyvanse withdrawal.

Is ADHD a disability? ›

Yes. Whether you view attention deficit hyperactivity disorder (ADHD) as neurological — affecting how the brain concentrates or thinks — or consider ADHD as a disability that impacts working, there is no question that the federal Americans with Disabilities Act (ADA) covers individuals with ADHD.

How do you know if Vyvanse is too strong? ›

Signs your Vyvanse dose is too high
  1. Anxiety.
  2. Constipation.
  3. Loss of appetite.
  4. Diarrhea.
  5. Dizziness.
  6. Dry mouth.
  7. Feeling jittery.
  8. Increased heart rate.
Feb 14, 2022

Can you drink caffeine with Vyvanse? ›

You may need to limit caffeine intake (food examples: coffee, teas, colas, and chocolate) while taking this medicine. Taking a high amount of caffeine can increase the risk of irritability, nausea, nervousness, palpitations, problems with sleep (insomnia), rapid heartbeat, or other side effects.

What makes Vyvanse less effective? ›

Medications that increase the acidity of your urine can make Vyvanse less effective. This might be difficult to research on your own, so be sure to ask your healthcare provider or pharmacist about drug interactions. One example of an acidifying medication is potassium phosphate (K-Phos).

Is Vyvanse a narcotic? ›

Vyvanse is a type of stimulant drug called an amphetamine. Vyvanse isn't a narcotic. Narcotics are opioid drugs.

Can I drink while on Vyvanse? ›

The manufacturer of Vyvanse does not offer any warnings that drinking alcohol is dangerous while taking Vyvanse.

How do you know when Vyvanse kicks in? ›

Vyvanse (lisdexamfetamine): Vyvanse is a prodrug, which means it needs to be taken orally and metabolized by the body's enzymes to become effective. Because of this, it can take approximately one to two hours to take effect and lasts approximately 14 hours.

What are the long term effects of Vyvanse? ›

Long-term side effects of Vyvanse may include: blood flow problems in your fingers and toes, including Raynaud's phenomenon. heart problems, such as high blood pressure, stroke, or heart attack. mental health conditions, such as psychosis (loss of contact with reality) or mania (periods of extreme excitement and energy ...

How long does Vyvanse last in a day? ›

How long does Vyvanse last? Vyvanse (lisdexamfetamine dimesylate) improves focus for up to 14 hours.

Does Vyvanse work the first day? ›

In adults with ADHD, Vyvanse was shown in clinical studies to improve attention at 2 hours and up to 14 hours after taking a dose. In children with ADHD, aged 6-12, Vyvanse was shown to start working within 1.5 hours after taking the medication and up to 13 hours after the morning dose.

Does Vyvanse wake you up? ›

Vyvanse is a stimulant that lasts 24 hours, so some people find it disrupts their sleep cycle, says Donaldson. If you are having trouble sleeping at night, she recommends taking your dose in the morning instead.

Will Vyvanse help me focus? ›

Vyvanse and Adderall are used by many people to treat attention deficit hyperactivity disorder (ADHD). Both are stimulants called amphetamines. They work by raising levels of chemicals in your brain called dopamine and norepinephrine that help you focus, control your impulses, and pay attention at school or work.

Should I take Vyvanse every day? ›

No, there is no twice-daily dosing recommendation for this drug. It's only taken once a day, usually in the morning. Taking Vyvanse later in the day or evening can cause trouble sleeping. So it's recommended that you take the drug in the morning to avoid this side effect.

When is the best time to take Vyvanse? ›

Vyvanse should be taken once a day in the morning exactly as your doctor tells you to take it. Vyvanse can be taken with or without food.

What is the strongest stimulant for ADHD? ›

It's called Adhansia XR and its active ingredient is methylphenidate, which has been used to treat ADHD for more than 50 years.

Which ADHD Med is best for anxiety? ›

Qelbree is a selective selective norepinephrine reuptake inhibitor that is used in the treatment of both depression and anxiety and that has also been shown to be effective in treating ADHD.

How do you know if ADHD meds are too high? ›

Signs your ADHD medication is too high
  1. Significantly increased anxiety or depression.
  2. Feeling “too wired”, especially into the evening.
  3. Severe Insomnia.
  4. New tics.
  5. Extreme irritability or agitation.
  6. Hallucinations.
  7. No appetite and significant weight loss.
  8. No longer feel like yourself, “sparkle” is gone.

How strong is Vyvanse? ›

Vyvanse oral capsules come in the following strengths: 10 milligrams (mg), 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, and 70 mg. Vyvanse chewable tablets come in the following strengths: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, and 60 mg.

What is the most effective ADHD medication? ›

MOST AND LEAST EFFECTIVE ADHD MEDICATIONS ACCORDING TO CAREGIVERS
MedicationExtremely or Very EffectiveDampened Personality
Adderall38.09%23.54%
Dexedrine37.68%24.62%
Strattera14.66%18.48%
Other meds46.92%10.32%
5 more rows
Mar 31, 2022

What's better than Vyvanse? ›

Adderall has been around longer than Vyvanse. The Food and Drug Administration (FDA) approved Adderall in 1996 and approved Adderall XR, a longer-acting, once-daily formulation of the same chemical compounds in 2002.

Can Vyvanse cause bipolar disorder? ›

Conditions of concern. Vyvanse can cause new or worsening symptoms in people who have bipolar disorder, thought problems, or psychosis. These symptoms may include delusions, hallucinations, and mania.

Can Vyvanse help bipolar? ›

Stimulant medication may exacerbate some symptoms of bipolar disorder, including psychosis. 1 A doctor who is considering prescribing this drug needs to carefully evaluate the symptoms of the individual patient.

How do I get rid of Vyvanse brain fog? ›

Eat well and stay hydrated. It is easy for patients on Vyvanse to become so focused on tasks that they forget to eat and drink regularly. Eating three healthy meals and drinking water throughout the day can minimize crash symptoms such as low energy, shakiness, irritability, or brain fog.

How does lisdexamfetamine affect the brain? ›

Lisdexamfetamine is a central nervous system stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control. Lisdexamfetamine is used to treat attention deficit hyperactivity disorder (ADHD) in adults and in children who are at least 6 years old.

How does lisdexamfetamine work for ADHD? ›

These drugs are often used to treat similar conditions. Lisdexamfetamine works by increasing levels of certain brain chemicals. This helps improve concentration and focus, and reduce hyperactivity and impulsiveness.

Is lisdexamfetamine dimesylate a stimulant? ›

Lisdexamfetamine Dimesylate (Vyvanse), A Prodrug Stimulant for Attention-Deficit/Hyperactivity Disorder.

Is lisdexamfetamine dimesylate a controlled drug? ›

Lisdexamfetamine is a schedule 2 controlled drug and therefore the legal requirements for controlled drug prescribing is required.

Can Vyvanse cause permanent damage? ›

Rarely, Vyvanse can cause side effects that last longer or that cause long-term problems. These effects can include: cardiovascular (heart and blood vessel) problems, including increased blood pressure, heart attack, and stroke* blood circulation problems in your fingers and toes, including Raynaud's disease*

Will Vyvanse give me motivation? ›

When you first start taking Vyvanse, you might experience a boost in energy, motivation and positivity. However, these effects don't typically last, says Dr. Lieberman.

Does Vyvanse give you energy? ›

Vyvanse is a medication that doctors prescribe to treat attention deficit hyperactivity disorder or binge eating disorder. It is a stimulant, which helps a person to concentrate. Because Vyvanse is a stimulant, a person may feel depressed or fatigued when it begins to wear off.

Who should not take Vyvanse? ›

Who should not take Vyvanse? You should not take Vyvanse if you: Are taking or have taken within the past 14 days an anti-depression medicine called a monoamine oxidase inhibitor (MAOI) Are sensitive to, allergic to, or had a reaction to other stimulant medicines.

What are the long term effects of taking Vyvanse? ›

Long-term side effects of Vyvanse may include: blood flow problems in your fingers and toes, including Raynaud's phenomenon. heart problems, such as high blood pressure, stroke, or heart attack. mental health conditions, such as psychosis (loss of contact with reality) or mania (periods of extreme excitement and energy ...

What happens when you take Vyvanse and don't have ADD? ›

Many high school and college students begin to abuse Vyvanse and other stimulants for this reason. However, research has shown that when students who do not have ADHD take Vyvanse and other stimulants, they actually have a lower GPA 5.

Does Vyvanse make you lose weight? ›

What is Vyvanse? Vyvanse is a prescription medicine used for the treatment of moderate to severe binge eating disorder (B.E.D.) in adults. Vyvanse is not for weight loss.

Is Vyvanse a narcotic? ›

Vyvanse is a type of stimulant drug called an amphetamine. Vyvanse isn't a narcotic. Narcotics are opioid drugs.

How much Vyvanse can you take in a day? ›

The recommended dosage for ADHD is 30 mg to 70 mg per day. A dose in this range is considered an average Vyvanse dose. However, be sure to take the dose your doctor prescribes. The maximum Vyvanse dosage is 70 mg per day.

Videos

1. Switching To Elvanse (Vyvanse) From Concerta (Generic) 💊 First Impressions
(Stuart Anderson)
2. Why is Vyvanse so Popular | ADHD | Episode 82
(Dr. John Kruse)
3. One week on Elvanse/Vyvanse - Pro's and Con's - ADHD
(OllieEdward)
4. Lisdexamfetamine or Vyvanse Medication Information (dosing, side effects, patient counseling)
(RxLearn)
5. Mechanism of Action Animation | ADHD
(Random42 Scientific Communication)
6. ADD: My Experience With Vyvanse
(Travis McBee)

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